Queen

Queen is a boss enemy in Slay the Spire 2, entering combat with 400 HP (419 on higher Ascensions).

Its attack pattern runs Starts: Puppet Strings → You Are Mine; then conditional: Burn Bright for Me (if does not have amalgam died) / Off with Your Head (if has amalgam died); then conditional: Burn Bright for Me (if does not have amalgam died) / Off with Your Head (if has amalgam died).

Its heaviest attack, Off with Your Head, deals 3×5 (15 total) damage.

Across community-tracked runs, the Queen fight proves fatal to 18.0% of the parties that reach it.