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Infested Prism is an elite enemy in Slay the Spire 2, entering combat with 161 HP (171 on higher Ascensions).
It cycles through Jab → Radiate → Whirlwind → Pulsate → repeat.
Its heaviest attack, Jab, deals 15 damage.
It opens the fight already holding Vital Spark.
Across community-tracked runs, the Infested Prism fight proves fatal to 7.8% of the parties that reach it.
Applied at the start of combat
Hits for 15 damage (17 on Ascension).
Hits for 11 damage (13 on Ascension) and gains 11 Block.
Hits 3 times for 5 (15 total) damage (6×3 = 18 on Ascension).
Hits for 8 damage (10 on Ascension), gains 20 Block, and gains 2 Vital Spark.
Where Infested Prism shows up.
In 428,567 community runs, the Infested Prism fight was fatal to 7.8% of runs (33,428), dealing an average of 32.4 damage over 5.52 turns.
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